Correlation of global longitudinal strain with disease severity in liver cirrhosis

Abstract Funding Acknowledgements Type of funding sources: None. Introduction/purpose Cirrhotic cardiomyopathy is characterized by high cardiac output, reduced peripheral resistance and diastolic dysfunction has been correlated with cirrhosis severity prognosis. Global longitudinal strain (GLS) a sensitive marker which considered relatively independent preload afterload conditions thus may be diagnostic significance in this special population. We sought to investigate alterations GLS relating disease cirrhotic patients. Methods Echocardiographic analysis 51 consecutive patients was performed. Images were acquired analyzed off-line. calculated semi-automatic way using dedicated software. Clinical biochemical examination used assess liver calculating Child-Pugh class (class C have more severe than B A patients) MELD-Na score (increased as the progresses). Results Mean age 58.4 ± 8.7 years, 38 (74.5%) males. Among patients, 22 (43.1%) A, 17 (33.3%) 12 (23.5%) mean 15.3 7.5. left ventricular end-systolic volume (LVEDV) 117 29ml, stroke (SV) 72.5 19.9ml , ejection fraction (LVEF) 61.0 5.0%, systolic blood pressure (SBP) 128 13mmHg, ratio peak transmitral annular (septal) velocity during early diastole (E/e’ ratio) 10.4 4.5, atrial index (LAVI) 37.4 11.8 ml/cm2 -21.6 2.6%. (-20.3 2.4) higher (less negative) (-22.2 2.2) (-23.0 2.8) Difference between groups non-significant (figure). Severity determined LAVI (r = 0.592, p < 0.001), SV 0.554, (r=-0.441, 0.001) LVEDV 0.428, 0.002). (r=-0.369, 0.008) but not (LVEDV), or (SBP). In linear regression model, independently associated Meld-Na when adjusting for age, SBP, NASH etiology [B=-0.139 (-0.252; -0.025), 0.018]. Conclusions lower (more progresses relation affected conditions. Further research works are required explain underlying pathophysiology prognostic values advanced cirrhosis. Figure. stratified